Diesel engines are utilized in most of heavy duty vehicles as their good performance. However, fossil fuel is being depleted currently, and emissions from diesel engine contains many toxic substances such as CO, HC, NOx, PM…which effect adversely on environment and human health. Therefore, research and application of alternative fuels which are renewable and environment friendly are under consideration in countries and as well as Vietnam. Among these fuels, Dimethyl Ether (DME) is considered as the potential fuel for diesel engine.